… Existing experimental evidence suggests a role for α 2 -… Since the α 2 -adrenergic receptor
agonist tizanidine can … release of SP in the mouse spinal cord [89]. As discussed earlier, since …

… The purpose of this study was to compare the synergistic anti-… antinociceptive effect of tizanidine
(3 mg/kg, po), tizanidine … that tizanidine has a similar anti-inflammatory action to clonidine…

… did not observe any significant difference between DEX (5–… of phenylephrine and clonidine
decreased the expression of … these results suggest that alpha-adrenoceptor mechanism(s) …

… also mediate antinociceptive and hypothermic effects of some … clonidine, dexmedetomidine,
tizanidine and other agents [12]. … Compared to clonidine, mafedine has slower and more …

… blocks the rewarding and antinociceptive actions of morphine [28]. … binding is involved in
the anti-hypertensive effects of clonidine [… with lofexidine compared to clonidine. Other adverse …

… The locomotor activity of the mice was assessed in a … activity at a dose of 30 µg in both motor
activity measurement sessions. For comparison, clonidine decreased the motor activity at all …

… mice [F(3,21) = 1.078, P = 0.365] and in sham surgery mice [F(3,21) = 0.228, P = 0.877].
Compared to mice in sepsis group, mice … a role of α2A adrenoceptor in the protective effects of …

… receptor produces antinociception in mice without respiratory … have a key role in producing
adverse effects of opioids73. … Species differences or poor CNS activity may have led to this …

… indicate a significant difference compared to the control … antinociceptive effect of AA3052
is manifested by the C-terminal SP fragment that might activate other receptor systems involved …

… efficiency of intervention over control, adverse effects, study … following the use of tizanidine
when compared to that using a … efficiently deliver the central antinociceptive action of TN. The …